From Birmingham International Airport:
Leaving the airport, take I-20 west through downtown Birmingham. At the I-65 junction take I-65 South. At the I-459 junction take I-459 South. Exit off of I-459 South at Exit 13 (this is the first exit you come to). At the end of the exit ramp (traffic light), turn left. The Riverside Galleria and The Wynfrey are immediately on your right. Take the 2nd entrance into the Galleria complex. This will bring you to the entrance of The Wynfrey Hotel.
Time: Approximately 20 minutes

From Atlanta:
Take I-20 west to I-459 Junction (just east of Birmingham). Take I-459 South. Take exit #13 (Hoover-Pelham) off I-459 South. Turn Left. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 115 miles

From Chattanooga, TN
Take I-59 South to I-459 Junction (just east of Birmingham). Take I-459 South. Take exit #13 (Hoover-Pelham) off I-459 South. Turn Left. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 155 miles

From Huntsville, AL
Take I-65 South through Birmingham to I-459 junction. Take I-459 South. Take exit #13 (Hoover-Pelham) off I-459 South. Turn left. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 120 miles

From Jackson, MS
Take I-20 east to I-459 North (just west of Birmingham ) Take I-459 North. Take exit #13 (Hoover-Pelham) off I-459 North. Turn right. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 245 miles

From Memphis, TN
Take U.S. Highway 78 South to Birmingham. Take I-59/I-20 North/West towards Birmingham to I-65 South towards Montgomery, to I-459 South towards Tuscaloosa. Exit# 13 at the Hoover/Pelham and take a left onto Highway 31 and we're on the right hand side.
Approximately 250 miles

From Meridian, MS
Take I-59 North/I-20 East to I-459 Junction (just west of Birmingham ) Take I-459 North. Take exit #13 (Hoover-Pelham) off I-459 North. Turn right. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 140 miles

From Montgomery, AL
Take I-65 North to I-459 Junction (just south of Birmingham) Take I-459 South. Take exit #13 (Hoover-Pelham) off I-459 South. Turn left. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 90 miles

From Nashville, TN
Take I-65 South to I-459 through Birmingham. Take I-459 South. Take exit #13 (Hoover-Pelham) off I-459 South. Turn left. The Wynfrey Hotel is on the right, second Galleria entrance.
Approximately 200 miles